Thioredoxin Reductase



Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH. TrxR-2 is mitochondrial. The images at the left and at the right correspond to one representative TrxR, i.e. the crystal structure of Thioredoxin Reductase from Eschericia coli (1cl0).

3D Structures of Thioredoxin Reductase
Update June 2011

TrxR
1cl0, 1tde, 1trb – EcTrxR+FAD – Eschericia coli

1tdf - EcTrxR+FAD+NADPH

1f6m - EcTrxR (mutant)+Trx-1+FAD+AADPH

1h6v – rTrxR (mutant)+FAD+NADPH – rat

1vdc – TrxR+FAD – Arabidopsis thaliana

2a87 - TrxR+FAD+NADPH – Mycobacterium tuberculosis

3cty - TrxR+FAD – Thermoplasma acidophilum

3d8x - yTrxR+FAD+NADPH - yeast

2nvk - DmTrxR+FAD+NADPH – Drosophila melanogaster

2q0k, 2q0l - HpTrxR+FAD+NADPH – Helicobacter pylori

3ish - HpTrxR+FAD

2q7v - TrxR+FAD – Deinococcus radiodurans

3r9u – TrxR – Campylobacter jejuni

TrxR-1
2cfy – hTrxR-1+FAD – human

2zz0, 2zzb, 2zzc – hTrxR-1 (mutant)+FAD

2j3n – hTrxR-1+FAD+NADPH

3itj – yTrxR-1+FAD

3dh9, 3dgh – DmTrxR-1+FAD

3ean, 3eao – rTrxR-1+FAD+NADPH

TrxR-2
1zdl, 1zkq – mTrxR-2+FAD+NADPH – mouse

3dgz – mTrxR-2+FAD

2whd – TrxR-2+FAD – Hordeum vulgare

TrxR-3
3f8d, 3f8p, 3f8r – TrxR-3 (mutant)+FAD – Sulfolobus solfataricus

3h8q – hTrxR-3 glutaredoxin domain